產(chǎn)品詳情

  • 產(chǎn)品名稱：Tipifarnib,Freebase

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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Tipifarnib,Freebase
詳情介紹：
Characteristics A potent, selective, nonpeptidomimetic inhibitor of farnesyl protein transferase (FPT), an enzyme involved in protein processing (farnesylation) for signal transduction. Displays significant antitumor effects in vivo. Tipifarnib competitively inhibits the farnesylation of lamin B (IC50= 0.86 nM) and K-RasB (IC50= 7.9 nM) peptide substrates and inhibits the cell growth of ca. 75 % of a panel of 53 human tumor cell lines tested.
Purity ≥ 98?% by HPLC
Chemical Name (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one; R-115777
Formula C??H??Cl?N?O
Permeability Cell-permeable
Molecular Weight 489.4 g/mol
CAS-No 192185-72-1
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months
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image for Tipifarnib, Free base (ABIN1685610) Tipifarnib, Free base