產(chǎn)品詳情

  • 產(chǎn)品名稱：GW4869dihydrocloride

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  • 產(chǎn)品廠商：Biovision
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簡單介紹：
GW4869dihydrocloride
詳情介紹：
Characteristics GW 4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC50= 1 μM), but does not affect acid sphingomyelinase activity. It inhibits TNF-alpha-mediated sphingomyelin hydrolysis (100 % inhibition at 20 μM) and TNF-alpha-induced cell death in MCF7 cells without interfering with activation of NF-KB or glutathione depletion in response to TNF.
Purity ≥ 90?%
Chemical Name 3,?3'-?(1,?4-?phenylene)bis[N-?[4-?(4,?5-?dihydro-?1H-?imidazol-?2-?yl)phenyl]-?2-?propenamide, dihydrochloride; GW69A; GW554869A
Formula C??H??N?O? ? 2HCl [xH?O]
Permeability Cell-permeable
Molecular Weight 577.5 g/mol
CAS-No 6823-69-4
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 36 months
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image for GW 4869 dihydrocloride (ABIN1685845) GW 4869 dihydrocloride