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Characteristics
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Cell-permeable. A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (kDa≤ 7 nM). In contrast, inhibition of nNOS and eNOS is weaker and rapidly reversible with Ki values of 2 and 50 μM respectively. Inhibits tumor growth in vivo. Prevents circulatory failure but not organ injury induced by endotoxin. Displays protective effects in oxygen-deprived brain slices.
Synonyms: N-(3-(Aminomethyl)benzyl)acetamidine. 2HCl
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