Characteristics
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Cell-permeable. A potent inhibitor of Sonic hedgehog (Shh) signaling, high affinity antagonist of smoothened activity (kDa= 1.2 nM). Inhibits smoothened agonist effects with an IC50of 20 nM in Shh-LIGHT2 cells.SANT-1 inhibits both wild type and oncogenic Smo with equal potency.
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