Characteristics
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A potent inhibitor of CDK1 and CDK2 with Ki values of 9 and 6 nM and IC50values of 9.5 and 5.4 nM, respectively. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50= 1.6 μM), DYRK1A (IC50= 0.9 μM), PDK1 (IC50= 0.8 μM) and ROCK-II (IC50= 0.6 μM). Inhibits cell growth.
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