產(chǎn)品詳情

  • 產(chǎn)品名稱：AZD8055

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
AZD8055
詳情介紹：
Characteristics A potent, ATP-competitive inhibitor of mTOR kinase (both mTORC1 and mTORC2) with an IC50of 0.8 nM. AZD8055 displays excellent selectivity (ca. 1,000-fold) against all class I PI3K isoforms and other members of the PI3K-like kinase family. In addition, it shows no significant activity against a panel of 260 kinases at concentrations up to 10 μM. AZD8055 inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins.
Purity ≥ 98?% by HPLC
Chemical Name 5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Formula C??H??N?O?
Permeability Cell-permeable
Molecular Weight 465.54 g/mol
CAS-No 1009298-09-2
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 36 months
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image for AZD8055 (ABIN1685703) AZD8055