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Comment
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Synonyms:
SN50, AAVALLPAVLLALLAPVQRKRQKLMP
This peptide contains the nuclear localization sequence (NLS residues 360-369) of the transcription factor NF-B p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). SN50 inhibits translocation of the NF-B active complex into the nucleus. In mouse endothelial LE-II cells induced with LPS, inhibition of NF-B nuclear translocation was 88 % at 50 μg/mL (18 μM). In human monocytic THP-1 cells induced by LPS or TNF there was 85 % inhibition at 100 μg/mL
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