Characteristics
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Cell-permeable. A potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases (RTKs) with IC50 values of 0.06, 2.43, 3.04 and > 100 μM at PDGFRbeta, VEGFR2, FGFR1 and EGFR respectively. Acts as a potent antiangiogenic and antitumor agent.
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