Characteristics
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Inhibits non-apoptotic cell deathpathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1, partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5.
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