產(chǎn)品詳情

  • 產(chǎn)品名稱：SGC0946

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
SGC0946
詳情介紹：
Purpose A potent and selective DOT1L inhibitor
Characteristics White solid
Molecular formular: C28H40BrN7O4
Purity ≥ 98?% by HPLC
Chemical Name 1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-?bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydro?xytetrahydrofuran-2-yl]methyl](isopropyl)amino]pro?pyl]-3-[4-(2,2-dimethylethyl)phenyl]urea
Formula C??H??BrN?O?
Permeability Cell-permeable
Molecular Weight 618.57 g/mol
Comment

Synonyms:
1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea
A potent and selective DOT1L inhibitor (IC = 0. 3 nM in a radioactive enzyme assay), >100-fold selective for other histone methyltransferases (HMTs). SGC0946 also potently reduces H3K79 dimethylation with cellular IC of 2.6 nM in A431 cells, and 8.8 nM in MCF10A cells
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for SGC0946 (ABIN1889073) SGC0946