Synonyms: (S)-3-(1-((9H-purin-6-yl)amino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one IPI-145 is a potent inhibitor of phosphoinositide-3-kinase (PI3K)-d and PI3K- isoforms with potential immunomodulating and antineoplastic activities. IPI-145 prevents the activation of the PI3Kd/-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3Kd/-expressing tumor cells
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