Comment
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Synonyms: Retro-2(cycl), ( ±)-2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one, Ricin retrograde transport blocker An inhibitor of ribosome-inactivating proteins (RIPs). At a concentration of 200mg/kg, Retro-2 displayed full protection of mice against a dose of ricin that killed 90 % of an unprotected control mouse population. Blocks Leishmania parasitophorous vacuole (LPV) development. Retro-2 inhibited the replication of Leishmania parasites in axenic cultures
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