產(chǎn)品詳情

  • 產(chǎn)品名稱：Charybdotoxin

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Smartox-Biotech
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簡(jiǎn)單介紹：
Charybdotoxin
詳情介紹：
Purpose Charybotoxin blocks Kca channels
Sequence Pyr-Phe-Thr-Asn-Val-Ser-Cys7-Thr-Thr-Ser-Lys-Glu-Cys13-Trp-Ser-Val-Cys17-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys28-Met-Asn-Lys-Lys-Cys33-Arg-Cys35-Tyr-Ser-OH(Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35)
Background Charybdotoxin is a 37 amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus that blocks voltage gated and Ca2+ activated K+ channels. This blockade causes hyperexcitability of the nervous system. The toxin reversibly blocks channel activity by interacting at the external pore of the channel protein with an apparent Kd of 2.1 nM. ChTX also blocks Kv1.2 (Kd 14 nM) and Kv1.3 (Kd 2.6nM) channels.
Molecular Weight 4295.9 Da
CAS-No 95751-30-7
Restrictions For Research Use only