產(chǎn)品詳情

  • 產(chǎn)品名稱：μ-conotoxinCnIIIC

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Smartox-Biotech
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簡單介紹：
μ-conotoxinCnIIIC
詳情介紹：
Sequence AA sequence: Pyr-Gly-Cys3-Cys4-Asn-Gly-Pro-Lys-Gly-Cys10 -Ser-Ser-Lys-Trp-Cys15-Arg-Asp-His-Ala-Arg- Cys21-Cys22-NH2 Disulfide bonds: Cys3-Cys15, Cys4-Cys21 and Cys10-Cys22
Characteristics μ-conotoxin CnIIIC is a selective blocker of Nav1.4 channels
Background μ-conotoxin CnIIIC has been isolated from the venom of the marine cone snail Conus consors. μ-conotoxin CnIIIC exhibits a myorelaxing effect through specific blockade of the skeletal muscle Nav1.4 channels (IC50 = 1.4 nM). μ-conotoxin CnIIIC also blocks Nav1.2 channels (1 μM) and mildly Nav1.7. In contrast, Nav1.5 and Nav1.8 are insensitive to the action of the toxin. μ-conotoxin CnIIIC also blocks the α3β2 nicotinic acetylcholine receptor (IC50 = 450 nM) and to lesser extents the α7 and α4β2 subtypes. μ-conotoxin CnIIIC completely inhibits twitch tension in isolated mouse hemidiaphragms (IC50 = 150 nM).
Molecular Weight 2375.8 kDa
Restrictions For Research Use only
Storage -20 °C
Background publications Favreau, Benoit, Hocking, Carlier, D hoedt, Leipold, Markgraf, Schlumberger, Córdova, Gaertner, Paolini-Bertrand, Hartley, Tytgat, Heinemann, Bertrand, Boelens, St?cklin, Molgó: "A novel μ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors." in: British journal of pharmacology, Vol. 166, Issue 5, pp. 1654-68, 2012 (PubMed).

Markgraf, Leipold, Schirmeyer, Paolini-Bertrand, Hartley, Heinemann: "Mechanism and molecular basis for the sodium channel subtype specificity of μ-conopeptide CnIIIC." in: British journal of pharmacology, Vol. 167, Issue 3, pp. 576-86, 2012 (PubMed).