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  • 產(chǎn)品名稱(chēng)：Methyl-CpGBindingDomainProtein3(MBD3)(N-Term)Peptide

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Methyl-CpGBindingDomainProtein3(MBD3)(N-Term)Peptide
詳情介紹：
Blocked Antibody anti-MBD3 antibody (Methyl-CpG Binding Domain Protein 3) (N-Term) (ABIN2778641)
Characteristics This is a synthetic peptide designed for use in combination with anti-MBD3 antibody (Catalog #: ARP40170_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71?% and 94?% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71?% and 94?% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Alias Symbols: -

Protein Interaction Partner: BCL6,HDAC1,MTA2,AURKA,GATAD2A,GATAD2B,HDAC1,MBD2,MBD3,MBD3L1,MTA2,RBBP4,RBBP7,SPEN,AURKA,CHD4,GATAD2A,GATAD2B,HDAC1,HDAC2,MBD2,MBD3,MBD3L1,MECOM,MTA2,RBBP4,RBBP7,TRIM27

Protein Size: 291
Molecular Weight 33 kDa
Gene ID 53615
NCBI Accession NM_003926, NP_003917
UniProt O95983
Research Area Chromatin and Nuclear Signaling
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100?μL of sterile PBS. Final peptide concentration is 1?mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.