Characteristics
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A potent, selective and ATP-competitive mTOR inhibitor, with IC50values of 2 and 10 nM for mTORC1 and mTORC2 respectively, Torin1 displays 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases.
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