產(chǎn)品詳情

  • 產(chǎn)品名稱：UNC0638

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
UNC0638
詳情介紹：
Characteristics Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC50 value of < 15 nM in vitro. UNC0638 also inhibits GLP, a closely-related H3K9 HMTase, with an IC50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effect.
Purity ≥ 98?% by HPLC
Chemical Name 2-?Cyclohexyl-?6-?methoxy-?N-?[1-?(1-?methylethyl)-?4-?piperidinyl]-?7-?[3-?(1-?pyrrolidinyl)propoxy]-?4-?quinazolinamine
Formula C??H??N?O?
Permeability Cell-permeable
Molecular Weight 509.72 g/mol
CAS-No 1255580-76-7
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months
Supplier Images
image for UNC0638 (ABIN629336) UNC0638