Comment
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Synonyms: (S)-2-hydroxy-3-methyl-N-((S)-1-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino)-1-oxopropan-2-yl)butanamide , LY450139 A potent -secretase inhibitor (IC = 10.9 nM, 12.1 nM and 12.0 nM for A42, A40 and A38, respectively). Semagacestat has shown to reduce the rate of formation of amyloid- in vitro and in vivo
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