產(chǎn)品詳情

  • 產(chǎn)品名稱：Camptothecin(2mg/ml)

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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Camptothecin(2mg/ml)
詳情介紹：
Characteristics PubChem CID: 24360
Molecular Formula: C??H??N?O?
Cell Premeable: Yes
Purity > 98?% by TLC
Chemical Name (S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
Formula C??H??N?O?
Permeability Cell-permeable
Background Synonyms: (S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
Molecular Weight 348.4 g/mol
CAS-No 7689-03-4
Application Notes Reversibly inhibits nuclear topoisomerase I by binding to and stabilizing the topoisomerase- DNA covalent complex. Inhibits Tat-mediated transcription of HIV-1. Induces apoptosis in Jurkat, osteosarcoma and hepatoma cells.
Comment

Reversibly inhibits nuclear topoisomerase I by binding to and stabilizing the topoisomerase-DNA covalent complex. Inhibits Tat-mediated transcription of HIV-1. Induces apoptosis in Jurkat, osteosarcoma and hepatoma cells.
Restrictions For Research Use only
Format Liquid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 6 months
Supplier Images
image for Camptothecin (2 mg/ml) (ABIN412357) Camptothecin (2 mg/ml)
Product cited in: Berger, Capper, Lemke, Pfenning, Platten, Weller, von Deimling, Wick, Weiler: "Defective p53 antiangiogenic signaling in glioblastoma." in: Neuro-oncology, Vol. 12, Issue 9, pp. 894-907, 2010 (PubMed).

Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: "Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin." in: The American journal of pathology, Vol. 177, Issue 2, pp. 735-43, 2010 (PubMed).

Jensen, Andresen, Hansen, Skov: "Cell-surface expression of Hsp70 on hematopoietic cancer cells after inhibition of HDAC activity." in: Journal of leukocyte biology, Vol. 86, Issue 4, pp. 923-32, 2009 (PubMed).

Bull, Meadows, Coldren, Moore, Sotto-Santiago, Nana-Sinkam, Campbell, Geraci: "Human herpesvirus-8 infection of primary pulmonary microvascular endothelial cells." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 6, pp. 706-16, 2008 (PubMed).

Hirai, Nelson, Yamazaki, Takebe, Przybylo, Madden, Radisky: "Non-classical export of epimorphin and its adhesion to alphav-integrin in regulation of epithelial morphogenesis." in: Journal of cell science, Vol. 120, Issue Pt 12, pp. 2032-43, 2007 (PubMed).

Tonini, Gabellini, Bagella, DAndrilli, Masciullo, Romano, Scambia, Zupi, Giordano: "pRb2/p130 decreases sensitivity to apoptosis induced by camptothecin and doxorubicin but not by taxol." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 23, pp. 8085-93, 2004 (PubMed).