產(chǎn)品詳情

  • 產(chǎn)品名稱：Tamapin

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Smartox-Biotech
  • 產(chǎn)品文檔：
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簡單介紹：
Tamapin
詳情介紹：
Purpose Tamapin is a SK channel inhibitor
Sequence Ala-Phe-Cys3-Asn-Leu-Arg-Arg-Cys8-Glu-Leu-Ser-Cys12-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys21-Ile-Gly-Glu-Glu-Cys26-Lys-Cys28-Val-Pro-Tyr-NH2Disulfide bridges: Cys3-Cys21, Cys8-Cys26, Cys12-Cys28
Background Tamapin is a peptide toxin isolated from the venom of the Indian red scorpion Mesobuthus Tamulus. Tamapin is amidated at its C-terminal tyrosine residue (contrary to recombinant tamapin, Smartox’ tamapin is amidated). It binds to small conductance Ca2+-activated K+ channels (SK channels) with high affinity and inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus as well as in cell lines expressing distinct SK channel subunits. Tamapin is an excellent toxin to discriminate among SK channel subtypes because it presents different affinities for SK1 (42 nM), SK2 (24 pM) and SK3 (1.7 nM) channels. This toxin is also the most potent SK2 channel blocker characterized so far (IC50 for SK2 channels = 24 pM).
Molecular Weight 3459 Da
Restrictions For Research Use only